Cyclic Loading Microfluidic Chip

Single-Cell Dynamic Resilience Metrics

A microfluidic chip that applies cyclical mechanical loading to single cells and introduces dynamic resilience metrics to quantify cytoskeletal microdamage, enabling standardized mechanical biomarkers for chemotherapy susceptibility.

Xue, Chundong · Yu, Miao · Yang, Zhuo · Qin, Kairong

Analytical Chemistry 2025

Specifications

under flow rates

{'zh': '', 'en': '300'} μL/h

Advantages

Daunorubicin modulates cellular resilience concentration-dependently, with mechanosensitivity under large strain

Dynamic resilience metric quantifies chemotherapy-induced cytoskeletal microdamage in a dose-dependent manner