ROS-triggered intracellular release
Unlike conventional carriers, this polymer enhances protein binding via boronate ligands and achieves cytosolic release in response to intracellular reactive oxygen species, preserving protein bioactivity.
Lv, Jia · Yang, Zhen · Wang, Changping · Jianan, Duan · Ren, Lanfang · Rong, Guangyu · Feng, Qiuyu · Li, Yiwen · Cheng, Yiyun
Journal of Controlled Release 2023
Efficiently delivered saporin into osteosarcoma cells and tumor tissues
High therapeutic efficacy in an osteosarcoma mouse model