Sustained local anti-fibrotic release
An injectable thermosensitive hydrogel providing localized sustained Klotho release over 14 days; a single renal capsule injection attenuates renal fibrosis and the chitosan matrix itself induces endogenous Klotho, outperforming daily free Klotho or captopril.
Li, Chenyang · Wang, Shuai · Liao, Chenghui · Li, Ying · Zhou, Yunfeng · Wu, Haiqiang · Xiong, Wei
Biomaterials Research 2024
Gelation within 3 min at 37 °C
Sustained Klotho release over 14 d in PBS and in mouse kidneys
Single injection of KLO-Gel over 14 d more effective at reducing renal fibrosis than daily free Klotho or captopril
Chitosan induces endogenous Klotho secretion