Switchable Six-Membered N-Heterocycles

Green-Solvent Switch

Switchable synthesis between six-membered N-heterocycles and seven-membered O-heterocycles using green solvents EA and EtOH, providing polycyclic skeletons without tedious purification.

Wang, Liang · Jing, Wang · Xinyu, Wang · Xu, Lubin · Guo, Fengwei · Liu, Xiongli · Hu, Fangzhi · Li, Shuaishuai

Green Synthesis and Catalysis 2024

Advantages

One-step construction of polycyclic tetrahydropyrido[1,2-a]indole derivatives in EA

Dihydrodibenzo[b,e]oxepines obtained in moderate to good yields in EtOH

No purification needed