Chloroquinone Derivative

Broad-spectrum antifungal

A natural chloroquinone with potent activity against multiple plant pathogenic fungi, targeting succinate dehydrogenase.

Xing, Feng · Li, Ming · Wang, Bingui · Meng, Linghong

Phytochemistry 2025

Specifications

Minimum inhibitory concentration

{'zh': '0.5-4', 'en': '0.5-4'} μg/mL

Advantages

Destroys hyphal morphology

SEM and cryo-SEM analyses show that 9 strongly destroys the surface morphology of mycelia and interferes with fungal growth.

Inhibits succinate dehydrogenase

Compound 9 exhibited pronounced succinate dehydrogenase (SDH) inhibitory activity in vitro, and molecular docking simulations were performed to explore the intermolecular interaction with SDH.

Effective in vivo

In vivo testing on tomato fruits showed that 9 displayed considerable curative efficacy against F. oxysporum.

Applications

• Plant fungal disease control：Directly kills pathogenic fungi, replacing conventional chemical fungicides
• SDH inhibitor antifungal drugs：Serve as an SDH inhibitor lead for new antifungal drug development
• Agricultural preservatives：Applied postharvest on fruits and vegetables to control fungal rot