Camptothecin nanoparticles

Anticancer without gut barrier loss

Compared with high-dose camptothecin, these nanoparticles achieve superior breast cancer therapeutic efficacy while preserving intestinal barrier integrity and gut microbiota diversity.

Liu, Qingya · Yang, Yun · Pan, Meng · Shi, Kun · Wang, Meng · Qian, Zhiyong

Bioactive Materials 2024

Advantages

PCRHNs + Laser treatment efficacy superior to high-dose CPT

PCRHNs + Laser treatment maintains intestinal barrier integrity

PCRHNs + Laser treatment maintains intestinal microbiota diversity and abundance

Increases abundance of probiotic Lactobacillus