Tumor-specific delivery
An ionizable lipid library with biodegradable moieties enables cell-specific delivery of biomacromolecules such as proteins and nucleic acids to tumor cells, with controlled release inside the cells.
Zheng, Qizhen · Tianyu, Ma · Wang, Ming
Accounts of Chemical Research 2023
Constructed an extensive library of ionizable lipids with different biodegradable moieties
Controlled degradation and release of therapeutics within tumor cells
Delivered bacterial effector proteins to regulate tumor cell signaling