Zn-IMP 3D Coordination Polymer

pH-responsive release

A zinc-based 3D coordination polymer for hydroxyurea delivery that triggers drug release under acidic tumor microenvironment conditions.

Zhu, Yanhong · Khan, Yaqoot · Irfan, Muhammad · Li, Hui

Polymers 2025

Specifications

with HU G

{'zh': '0.12', 'en': '0.12'} kcal·mol⁻¹

with HU G

{'zh': '0.26', 'en': '0.26'} kcal·mol⁻¹

Advantages

CP-1 ligand RMSD increases markedly at acidic pH

Chiral distorted tetrahedral geometry (P2₁ space group)