Spirooxindole-Dihydrofurans

Tunable Cyclization

Controllable synthesis of two highly functionalized spiro N/O-heterocyclic scaffolds via formal [3+2] and [5+2] cyclization strategies.

Zhipeng, Sun · Hou, Ranran · Li, Shuaishuai · Xinyu, Wang · Wang, Liang · Hu, Fangzhi

Organic Letters 2023

Advantages

Construction of spirooxindole-dihydrofurans via formal [3+2] cyclization

Construction of spirooxindole-benzazepines via formal [5+2] cyclization

Products bear amino, amide, and cyano groups amenable to late-stage functionalization