Oral delivery rivals IV
Carrying high-energy phosphate bonds, these nanorobots cross the intestinal barrier after oral administration, chemotactically target damaged cardiomyocytes, and sustain ATP synthesis for 12 hours with efficacy comparable to intravenous injection.
Li, Nan · Zhou, Min · Wu, Ziyu · Chen, Yu · Duan, Yu · Zhuolin, Wu · Shen, Jian · Mao, Chun · Wan, Mimi
Advanced Materials 2025
Energy supply duration: 12 h
200 µg AMNs emulate 5 × 10⁶ natural mitochondria in restoring energy metabolism