Dual-targeted NIR-II Theranostic Nanoparticles

Kills tumor and stroma simultaneously

NIR-II imaging-guided nanoparticles that simultaneously target tumor cells and immunosuppressive stroma, enabling precise imaging and photodynamic elimination of both compartments.

Wang, Mengqi · Gu, Ziyue · Li, Yuanyuan · Zhang, Jiayi · Wang, Mengyao · Wang, Zhiyong · Liu, Laikui · Tang, Benzhong · Zhang, Ming · Zhu, Weiwen

Biomaterials 2026

Advantages

Simultaneously clears tumor and CAFs

Dually conjugated antibodies target both HNRNPC-high tumor cells and ITGA1+ myCAFs, enabling selective photodynamic elimination of both populations.

Restores anti-tumor immunity

Elimination of ITGA1+ myCAFs reverses CD8+ T cell exhaustion and reinstates anti-tumor immunity.

Applications

• Targeted therapy for oral squamous cell carcinoma：Selectively eliminates HNRNPC-high OSCC cells while sparing normal tissue.
• Photodynamic therapy：808 nm laser triggers localized photodynamic action for spatiotemporally controlled tumor killing.
• Tumor phototheranostics：NIR-II imaging guides therapy, allowing real-time tumor tracking and treatment evaluation.
• Cancer immunotherapy：Removes immunosuppressive stroma, reversing T cell exhaustion to boost anti-tumor immunity.