Axially Chiral Tetrasubstituted Alkenes

Cu-catalyzed atom-economical

First enantioselective synthesis of axially chiral alkenes via vinyl cations, overcoming high steric hindrance and low conformational stability.

Gao, Liu · Sun, Miao · Lu, Xin · Hong, Xin · Wu, Ye · Zhou, Bo

Angewandte Chemie - International Edition 2024

Advantages

First vinyl cation approach for axially chiral alkenes

Copper-catalyzed C(sp2)-H functionalization

High atroposelectivities