Pazopanib Hepatotoxicity Model

Reveals hepatotoxicity mechanism

Elucidates the key pathway of pazopanib-induced hepatotoxicity via HSPA5 activation and ER stress, providing intervention targets.

Chen, Jian · Zhu, Tieming · Deng, Yaping · Jiang, Guojun · He, Qiaojun

Journal of Pharmacy and Pharmacology 2024