Thiazole Carbene Copper Catalyst

Air-Stable & Highly Active

This cationic homoleptic Cu(I) thiazol-2-ylidene complex catalyzes ketone alkynylation without stoichiometric copper acetylides, combining high reactivity with operational robustness.

Wang, Ruihong · Zhang, Jin · Hang, Yang · Yan, Guo · Szostak, Roman · Szostak, Michal

Organic Chemistry Frontiers 2025

Advantages

Air- and moisture-stable

Catalyzes alkynylation of ketones without stoichiometric Cu-acetylides