Crosses BBB, co-delivers mRNA and nanozymes
Simultaneously delivers mRNA drugs and metallic nanozymes to target ER-mitochondria crosstalk, inhibiting microglial overactivation and promoting M2 polarization to alleviate neuroinflammation and depressive-like behaviors.
Bai, Zetai · Jiwei, Wang · Zheng, Li · Liu, Sangni · Zhang, Ling · Gao, Fenglei · Xie, Chunming
Advanced Materials 2025
Significantly alleviates LPS-induced neuroinflammatory responses
Markedly ameliorates anxiety- and depression-like behaviors