Sustained Release for Hydrophilic Drugs
Achieves sustained release of hydrophilic drugs via borate-mediated dynamic covalent complexation, overcoming the limitation of conventional delivery vehicles designed for hydrophobic drugs.
Wang, Jingjie · Liu, Xinxin · Chen-chen, Zhu · Wang, Tianzuo · Si-Yu, Wang · Yan, Liu · Xin-Yang, Pan · Liu, Minhua · Ding, Chen · Li, Lingli · Zhou, Zhimin · Nan, Kaihui
Journal of Controlled Release 2023
Sustained release, low corneal permeation, and extended ocular retention
Biocompatibility verified in both in vitro and in vivo studies
Superior therapeutic effects over PBS, hydrogel vehicle, and free DQS in a mouse dry eye model