Sulfonamides by Photoredox/Copper Catalysis

Direct one-step synthesis

A cooperative photoredox and copper catalysis enables direct sulfonamide synthesis from aryl radical precursors, readily available amines, and a sulfur dioxide source in air at room temperature, obviating the need for prefunctionalized sulfur reagents.

Zhang, Mingjun · Lixia, Liu · Beibei, Wang · Yin, Yang · Liu, Yuxiu · Wang, Ziwen · Wang, Qingmin

ACS Catalysis 2023

Advantages

Under air and at room temperature

One-step synthesis of various sulfonamides

Various electron-rich and electron-deficient amines react smoothly