Cascaded Tapered Seven-Core Fiber Biosensor

Zhang, Zhichao; Tian, Zhen; Yao, Yicun; Bingwu, Yang; Zhang, Jingao; Haili, Ma; Rao, Lan; Wang, Kuiru; Yan, Binbin; Sang, Xinzhu; Chongxiu, Yu; Fu, Bo; Pu, Shengli; Yuan, Jinhui; Wu, Qiang

Cascaded Tapered Seven-Core Fiber Biosensor

Ultralow Detection Limit

Detects p53 in cancer cell lysate within minutes, with sensitivity far exceeding conventional western blotting.

Zhang, Zhichao · Tian, Zhen · Yao, Yicun · Bingwu, Yang · Zhang, Jingao · Haili, Ma · Rao, Lan · Wang, Kuiru · Yan, Binbin · Sang, Xinzhu · Chongxiu, Yu · Fu, Bo · Pu, Shengli · Yuan, Jinhui · Wu, Qiang

Talanta 2025

Specifications

Detection range: {'zh': '0.0496', 'en': '5'} ng/mL

Advantages

Detects p53 in 293T cell lysate, LoD far lower than WB

Rapid detection, good stability, specificity, high sensitivity