Efficient Chiral Amine Synthesis
A manganese catalyst that accomplishes asymmetric hydrogenation of pyridyl cyclic N-alkyl imines, a class of substrates that typically poison noble metal catalysts, outperforming noble metal counterparts and directly yielding S-nicotine and other chiral amines.
Yang, Jitao · Wang, Zheng · Wang, Yizhou · Dexin, Fu · Liu, Qingbin · Solan, Gregory A. · Ma, Yanping · Sun, Wenhua
Organic Letters 2025