Sustained release of rhNGF
An eye drop formulation using hypotonic PF127 hydrogel as an excipient, which prolongs rhNGF retention on the ocular surface via shear-thinning and in-situ gelation, enhancing corneal nerve repair.
Yili, Yao · Lei, Wang · Jiangtao, Ding · Xin-Yang, Pan · Lin-xing, Yang · Chang-rong, Guo · Yuan-hao, Wang · Gruber, Reinhard · Nan, Kaihui · Li, Lingli
Journal of Controlled Release 2025
In vitro release study showed fast and sustained rhNGF release
Preclinical testing in mice: reduced corneal epithelial defect size and increased corneal nerve density
Schirmer's test revealed improved corneal nerve function based on tear secretion