Chiral N-Alkylated Aromatic Amines

Bulky amines tolerated

Circumvents transmetalation via an outer-sphere nucleophilic attack, enabling efficient radical N-alkylation of sterically congested aromatic amines for chiral amine synthesis.

Du, Xuan · Fang, Jia · Chen, Ji · Shen, Boming · Liu, Wei · Zhang, Yong · Yang, Yuan · Gu, Qiang Shuai · Yu, Peiyuan · Liu, Xinyuan

Journal of the American Chemical Society 2024

Advantages

>110 examples

Catalyst-controlled stereoselectivity