On-demand tendon-bone healing
A 3D porous hydrogel that responds to the hypoxic, acidic, high-ROS tendon-bone microenvironment for on-demand DFO release, upregulating HIF-1α to promote early angiogenesis and bone formation for faster integration.
Chengzhong, Xu · Tao, Lin · Xiaoliang, Zhao · Yanchang, Gan · Jianxing, Huang · Zhang, Jie · Haibin, Zheng · Chunyi, Pu · Lin, Rurong · Bing, Yan · Guoju, Hu · Qiaolan, Liu · Yu, Bo · Li, Songjian · Hou, Honghao
Composites Part B: Engineering 2023
Effectively upregulates HIF-1α, VEGF, BMP-2 and Runx2 expression
Effectively resists oxidative stress, reduces ROS and inflammatory response
In vivo micro-CT, histological and biomechanical analyses confirm promoted early and rapid tendon-bone healing