Self-reinforcing chemodynamic therapy
A siRNA-embedded zero-valent iron nanoparticle that achieves self-reinforcing chemodynamic therapy by downregulating ferritin heavy chain, overcoming intracellular iron detoxification to efficiently generate hydroxyl radicals in cancer cells.
Wang, Jun · Hongye, Ding · Zhu, Yang · Yina, Liu · Meili, Yu · Cai, Huilan · Ao, Rujiang · Hongwei, Huang · Peng, Gong · Yaxin, Liao · Zhaolin, Chen · Lin, Lisen · Xiaoyuan, Chen · Yang, Huanghao
Angewandte Chemie - International Edition 2023
Releases Fe2+ and siRNA in acidic endo/lysosomes
O2 depletion causes intracellular pH decrease
⋅OH generation facilitates endo/lysosomal escape of siRNA
FHC downregulation enhances CDT