Precisely repairs spinal neurons
A neural stem cell membrane-coated nanoplatform delivering the natural product Enocyanin degrades GGT1 to inhibit ferroptosis and precisely remodels neurons at the site of spinal cord injury.
Tao, Yang · Ye, Lei · Xie, Peigen · Chen, Jian · Heng, Zhao · Chen, Xi · Ding, Jianing · Xintian, Ding · Zhao, Fengdong · You, Tao
Advanced Science 2026
At single-cell resolution, NSCm@EA precisely remodels neuronal subpopulations, selectively expanding γ-motor neurons
upregulates synaptic genes Gria2 and Negr1
suppresses inflammatory and oxidative stress pathways