Pd-Catalyzed Indole Vinyl Ether

High-Yield N,O-Aminals

A palladium-catalyzed hydroamination of indoles with vinyl ethers to afford N,O-aminal indoles, featuring mild conditions and broad functional group tolerance for rapid library construction.

Wang, Bowen · Li, Jianxiao · Wu, Wanqing · Huang, Liangbin · Liu, Qi · Jiang, Huangfeng

Chemistry - A European Journal 2025

Advantages

Atom-economic hydroamination

Good functional group tolerance

Broad substrate scope

Complete N1-regioselectivity