PQS Quorum-Sensing Metabolite

Precisely Induces Ferroptosis

Specifically induces ferroptosis in macrophages via a CNMT-TFR1 methylation axis, offering a new target for anti-infective therapy.

Jia, Tianyuan · Anmin, Ren · Liu, Yang · Tan, Chris Soon Heng · Yang, Liang

Nature Communications 2025

Advantages

PQS induces ferroptosis in macrophages in an iron- and lipid peroxidation-dependent manner

CNMT is the direct intracellular receptor of PQS in macrophages

PQS binding enhances the histidine methyltransferase activity of CNMT