Reverses immunosuppressive microenvironment
Integrates immune adjuvant GM-CSF with chemotherapeutic DOX in one nanocarrier, using SWCNT photothermal effect for controlled release, synergistically polarizing macrophages and enhancing anti-proliferative efficacy.
Wang, Miao · Zhang, Jiayu · Jiaruo, Tang · Cai, Xiaomeng · Dou, Rui · Guo, Chen · Hu, Yi · Chen, Jun
JCIS Open 2023
Co-delivery nanoplatform controls release of GM-CSF and DOX via SWCNT photothermal effect
GM-CSF pre-treated macrophages enhance anti-proliferative efficacy of DOX
Synergistic effect verified in MB49 cells