Bimetallic decarbonylative coupling

First mechanochemical method

Ni/Cu cooperative catalysis enables highly chemoselective decarbonylative coupling of amides with heterocycles under solvent-free mechanochemical conditions, yielding privileged heterobiaryl scaffolds.

Zhang, Jin · Jiaojiao, Zhang · Yan, Wenxuan · Sijie, Zhou · Ma, Yangmin · Szostak, Michal L.

ACS Sustainable Chemistry & Engineering 2024

Advantages

First mechanochemical decarbonylative cross-coupling

High chemoselectivity