Anti-fibrotic fracture repair
This adhesive competitively binds sclerostin to simultaneously suppress bone resorption and pathological fibrosis, providing mechanical support while enhancing osteoporotic fracture healing.
Xiao, Tianhua · Zunlei, Gong · Dongming, Duan · Yu, Hui · Liu, Song · Wu, Zenghui · Wang, Le · Yang, Xuebin · Tronci, Giuseppe · Ning, Chengyun · Tan, Guoxing · Zhou, Lei
Nature Communications 2025
Degrades under acidic osteoporotic conditions
Binds firmly to irregular bone surfaces