Reshapes Tumor Mononuclear Phagocytes
Co-delivers a viral RNA analog and a fatty acid oxidation regulator to synergistically reprogram immunosuppressive tumor mononuclear phagocytes into anti-tumor effectors, enhancing checkpoint blockade efficacy.
Liu, Chang · Zhou, Yanfeng · Guo, Daoxia · Yan, Huang · Ji, Xiaoyuan · Li, Qian · Chen, Nan · Fan, Chunhai · Song, Haiyun
Advanced Science 2023
Induces M2-to-M1 macrophage repolarization
Induces tolerogenic-to-immunogenic dendritic cell differentiation
Restores sensitivity to anti-PD-1 therapy in checkpoint blockade-resistant breast and ovarian tumors